The problem of 'no fault' compensation for patients who suffer adverse effects as a result of their participation in clinical trials is discussed in the light of the guidelines issued by the Association of the British Pharmaceutical Industry (ABPI) and our recent experiences in reviewing protocols submitted to the local ethics of surgical research sub-committee. We have found a variety of qualifications being applied by pharmaceutical firms which are not in the spirit of the guidelines, let alone the interests of (...) the patient, and we suggest a means whereby the patients can be assured of fair treatment in the event of 'no fault' injury. (shrink)

Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

Zhizneopisanie -- Kniga znanii︠a︡ -- Ukazanii︠a︡ i nastavlenii︠a︡ -- Kniga o dushe.

Consider orthodox motivational judgment internalism: necessarily, A’s sincere moral judgment that he or she ought to φ motivates A to φ. Such principles fail because they cannot accommodate the amoralist, or one who renders moral judgments without any corresponding motivation. The orthodox alternative, externalism, posits only contingent relations between moral judgment and motivation. In response I first revive conceptual internalism by offering some modifications on the amoralist case to show that certain community-wide motivational failures are not conceptually possible. Second, I (...) introduce a theory of moral motivation that supplements the intuitive responses to different amoralist cases. According to moral judgment purposivism (MJP), in rough approximation, a purpose of moral judgments is to motivate corresponding behaviors such that a mental state without this purpose is not a moral judgment. MJP is consistent with conceptual desiderata, provides an illuminating analysis of amoralist cases, and offers a step forward in the internalist-externalist debates. (shrink)

The origin of paraconsistent logic is closely related with the argument, ‘from the assertion of two mutually contradictory statements any other statement can be deduced’; this can be referred to as ex contradictione sequitur quodlibet (ECSQ). Despite its medieval origin, only by the 1930s did it become the main reason for the unfeasibility of having contradictions in a deductive system. The purpose of this article is to study what happened earlier: from Principia Mathematica to that time, when it became well (...) established. The two main historical claims that I am going to advance are the following: (1) the first explicit use of ECSQ as the main argument for supporting the necessity of excluding any contradiction from deductive systems is to be found in the first edition of the book Grundzüge der Theoretischen Logik (Hilbert, D. and Ackermann, W. 1928. Grundzüge der Theoretischen Logik. Berlin: Julius Springer Verlag); (2) Łukasiewicz's position regarding the logical constraints against contradictions varies considerably from his studies on the principle of (non-) contradiction in Aristotle, published in 1910 and what is stated in his `authorized lectured notes' on mathematical logic that appeared in 1929. The two texts are: 1) a paper in German (Łukasiewicz, J. 1910. `Über den Satz des Widerspruchs bei Aristotles'. Bulletin International de l'Académie des sciences de Cracovie, Classe d'Histoire et de Philosophie, pp. 15–38) [English translation: Łukasiewicz, J. 1971. ‘On the principle of contradiction in Aristotle’, Review of Metaphysics, XXIV, 485–509]; and 2) a book in Polish. Łukasiewicz, J. 1910. O zasadzie sprzecznosci u Aristotelesa Studium krytyczne, Warsaw: Panstwowe Wydawnictwo Naukowe [German translation: Łukasiewicz, J. 1993. Über den Satz des Widerspruchs bei Aristotles. Hildesheim: Georg Olms Verlag]. The lecture notes were then published as a book (Łukasiewicz, J. 1958. Elementy Logiki Matematycznej. Warszawa: Panstwowe Wydawnictwo Naukowe [PWN] and then translated into English (Łukasiewicz, J. 1963. Elements of Mathematical Logic. Oxford, New York: Pergamon Press/the Macmillan Company). The second half of this article will concentrate on Łukasiewicz's position on ECSQ. This will lead me to propose that to regard him as a forerunner of paraconsistent logic by virtue of those early writings is accurate only if his book published in Polish is considered but not if the analysis is restricted to the paper originally published in German (as has been the case for the principal reconstructions of the history of paraconsistent logic). Furthermore, I will stress that in the 1929 book he presented one formalization of ECSQ as an axiom for sentential calculus and, also, he used ECSQ to defend the necessity of consistency, apparently independently of Hilbert and Ackermann's book. At the end, I will suggest that the aim of twentieth century usage of ECSQ was to change from the centuries-long philosophical discussion about contradictions to a more ‘technical’ one. But with paraconsistent logic viewed as a technical solution to this restriction, then, the philosophical problem revives but having now at one's disposal an improved understanding of it. Finally, Łukasiewicz's two different positions about ECSQ open an interesting question about the history of paraconsistent logic: do we have to attempt a consistent reconstruction of it, or are we prepared to admit inconsistencies within it? (shrink)

Gordon Baker and I had been colleagues at St John’s for almost ten years when we resolved, in 1976, to undertake the task of writing a commentary on Wittgenstein’s Philosophical Investigations. We had been talking about Wittgenstein since 1969, and when we cooperated in writing a long critical notice on the Philosophical Grammar in 1975, we found that working together was mutually instructive, intellectually stimulating and great fun. We thought that we still had much to say about Wittgenstein’s philosophy, and (...) it seemed to us that misinterpretations of passages in the Investigations were so extensive that it would be worth trying to write a detailed analytical commentary. It is difficult to recapture the excitement of those early days in being among the first to work on the microfilms and, subsequently, on the photocopies of Wittgenstein’s Nachlass. We spent many hundreds of hours poring over the typescripts and the often only semi-legible manuscripts, fascinated and privileged to be able to try to follow the development of the thoughts of a great philosophical genius. We talked endlessly about what we had found in Wittgenstein’s manuscripts and typescripts, and debated how it should be understood. The first fruit of our labours was Wittgenstein – Understanding and Meaning. Its guiding idea was to draw attention to the manner in which Wittgenstein linked the concepts of meaning, understanding and explanation, and so to bypass the connections between meaning, truth and truth-conditions that so fascinated philosophers of the 1970s, and to abandon the red-herring of assertion-conditions and anti-realism. After a hiatus of four years, during which time we wrote a controversial book entitled Frege – Logical Excavations and a polemical book on contemporary philosophy of language – Language, Sense. (shrink)

The goal of this paper is to provide a detailed reading of John Venn's Logic of Chance as a work of logic or, more specifically, as a specific portion of the general system of so-called ‘material’ logic developed in his Principles of Empirical or Inductive Logic and to discuss it against the background of his Boolean-inspired views on the connection between logic and mathematics. It is by means of this situating of Venn 1866 [The Logic of Chance. An Essay on (...) the Foundations and Province of the Theory of Probability. With Especial Reference to Its Application to Moral and Social Science, London: Macmillan] within the entirety of his oeuvre that it becomes both possible to revisit and necessary to re-articulate its place in the history of the frequency interpretation of probability. For it is clear that if Venn's approach to logic not only allowed him to establish its foundations on the basis of a process of idealization and define it as consisting of so-called hypothetical infinite series, bu.. (shrink)

This chapter contains section titled: Baker's New Conception Waismann and Wittgenstein Wittgenstein on the Psychoanalytic Analogy Wittgenstein's Methodology Reconsidered Wittgenstein and Ryle 1: Categorial Confusions Wittgenstein and Ryle 2: Logical Geography Baker's Wittgenstein.

"Plato's Statesman reconsiders many questions familiar to readers of the Republic: questions in political theory - such as the qualifications for the leadership of a state and the best from of constitution (politeia) - as well as questions of philosophical methodology and epistemology. Instead of the theory of Forms that is the centrepiece of the epistemology of the Republic, the emphasis here is on the dialectical practice of collection and division (diairesis), in whose service the interlocutors also deploy the ancillary (...) methods of myth and of models (paradeigmata). Plato here introduces the doctrine of due measure (to metrion) and a conception of statecraft (politikē) as an architectonic expertise that governs subordinate disciplines such as rhetoric and the military - doctrines later developed by Aristotle. Readers will find a sustained defence of the importance of expertise (technē or epistēmē) in the conduct of affairs of state, a robust (although not unqualified) defence of the rule of law, and an unsparing but nuanced critique of democratic government. The chapters in this volume provide a comprehensive and detailed philosophical engagement with the entirety of Plato's wide-ranging dialogue, with successive chapters devoted to the sections of the dialogue as it unfolds, and an introduction that places the dialogue in the context of Plato's philosophy as a whole. While not a commentary in the traditional sense, the volume engages with Plato's Statesman in its entirety" -- Publisher's description. (shrink)

Throughout its long history metaphysics has been variously conceived. At its most sublime, it has been taken to be the study of the super‐sensible, in particular of the existence of a god, the nature of the soul, and the possibility of an afterlife. When the young Ludwig Wittgenstein entered the lists, it was entirely reasonable to conceive of metaphysics in this manner. Its subject matter was held to be the language‐independent and thought‐independent de re necessities of the world. The Tractatus (...) is dominated by three problems: first, the nature of logic and logical necessity; secondly, the essence of the proposition and hence the characterization of the general propositional form; and thirdly, the intentionality of the proposition. Logical propositions are combinations of elementary propositions by means of truth‐functional logical connectives. The metaphysics adumbrated in the Tractatus, Wittgenstein thought, was required for the possibility of representation and for the possibility of logic. (shrink)

... 243-) INTRODUCTION §§243- constitute the eighth 'chapter' of the book. Its point of departure is a natural query with respect to the conclusion of the ...

Miranda Fricker appeals to the idea of moral-epistemic disappointment in order to show how our practices of moral appraisal can be sensitive to cultural and historical contingency. In particular, she thinks that moral-epistemic disappointment allows us to avoid the extremes of crude moralism and a relativism of distance. In my response I want to investigate what disappointment is, and whether it can constitute a form of focused moral appraisal in the way that Fricker imagines. I will argue that Fricker is (...) unable to appeal to disappointment as standardly understood, but that there is a more plausible way of understanding the notion that she can employ. There are, nevertheless, significant worries about the capacity of disappointment in this sense to function as a form of moral appraisal. I will argue, finally, that even if Fricker can address these worries, her position might end up closer to moralism than she would like. (shrink)